New melanoma-brain metastasis study may allow better effective treatments to cure brain tumors
In-depth study of cells inside melanoma brain metastases has shed light on details about the condition that could lead to the development of new treatments, as highlighted by a report. Gadgets360,
For those unaware, melanoma is a type of skin cancer and brain metastasis is a condition that occurs when cancer spreads from its original source to the brain., It is the cause of the majority of cancer-associated deaths, with the majority of cases being recorded with advanced melanoma.
For the study, researchers began sourcing frozen metastatic tumors from dozens of melanoma patients, The researchers highlight that this is typically done on fresh brain samples, which are short in supply, which also limits the number of tumors that can be analyzed. On the other hand, we have many frozen melanoma samples in our tissue bank.
The researchers highlight that the technique showed the tumor’s biology and its microenvironment by helping them analyze tissues from patients who were not treated. After analyzing genes from more than 100,000 individual cells, the researchers found that melanoma brain metastases were more unstable, chromosomally, than those found in other parts of the human body.,
One of the first authors of the study, Johannes C. Melames revealed that chromosomal instability triggers signaling pathways that promote the proliferation of cells while blocking the immune system.
Given this pressure point, Meles has revealed that they are soon going to be testing a number of experimental drugs that affect chromosome instability in humans. He says he now has the rationale to evaluate these drugs in patients with melanoma metastasis to the brain.
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